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desvenlafaxine will enhance the degree or outcome of codeine by influencing hepatic enzyme CYP2D6 metabolism. Use Warning/Monitor. Desvenlafaxine inhibits CYP2D6; with greater desvenlafaxine doses (ie, four hundred mg) minimize the CYP2D6 substrate dose by nearly fifty%; no dosage adjustment wanted with desvenlafaxine doses 7 consecutive times stra